SAFETY DATA SHEET. 1. Identification. Product identifier: DIMETHYLFORMAMIDE. Other means of identification. Product No.: , . View or download the N,N-Dimethylformamide MSDS (Material Safety Data Sheet) or SDS for from Merck. Print Date 05/08/ SECTION 1. PRODUCT AND COMPANY IDENTIFICATION. Product name.: N,N-Dimethylformamide. MSDS Number.
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In Trost, Barry M. LC Lo lowest published. The pharmaceutical industry uses DMF as a reaction and crystallization solvent because of its exceptional dimethylformamiee parameters. DMF was first prepared in by the French chemist Albert Verley 8 January — 27 Novemberby distilling a mixture of dimethylamine hydrochloride and potassium formate.
If a country is not listed for a region, contact Eastman for further information. DMF is also used in epoxy based formulations.
Dimethylformamide – Wikipedia
Retrieved from ” https: The solvent properties of DMF are particularly attractive because of the high dielectric constant, the aprotic nature of the solvent, its wide liquid range and low volatility. Polymers like polyvinylchloride, vinylchloride- vinylacetate copolymers and some polyamides are also readily dissolved in DMF. Those aliphatics are used in lube oils.
The acute LD50 oral, rats and mice is 2. London, ; pp 35— Product Availability Check with local Sales Office to determine exact availability by country. On a pilot plant scale, on the other hand, several accidents have been reported.
It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticidesand in the manufacture of adhesivessynthetic leathersfibers, films, and surface coatings. You may be trying to access this site from a secured browser on the server. The Royal Society dimethylrormamide Chemistry. NN -Dimethylformamide . DMF is also used as industrial paint stripper.
Inorganic and organic based residual fluxes are highly soluble in DMF; therefore this solvent is used as a cleaner, for instance to clean hot-dip tinned parts. The primary use of DMF is as a solvent with low evaporation rate. Return to previous page. It facilitates reactions that follow polar mechanisms, such as S N 2 reactions.
Retrieved 27 June It is frequently used for chemical reactions and other applications, which require a high solvency power. From Wikipedia, the free encyclopedia. Distillation is therefore conducted under reduced pressure at lower temperatures. DMF is hydrolyzed by strong acids and bases, especially at elevated temperatures. DMF is dimethylfodmamide used as a solvent, reagent and catalyst in the synthetic organic chemistry. Resources Active, excipient, and dimethylvormamide ingredients for pharmaceuticals Eastman ingredients for pharmaceuticals.
LD 50 median dose. Lethal dose or concentration LDLC:. Contact Us Customer Center.
HHHHH DMF undergoes decarbonylation near its boiling point to give dimethylamine. Another significant application is the use of DMF as a solvent for polyurethane-based coatings on leather and artificial leather fabrics.
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As its name indicates, it is a derivative of formamidethe amide of formic acid. DMF is a polar hydrophilic aprotic solvent with a high boiling point. Authorized Distributors Please select a region and country for a list of authorized distributors.
On a laboratory scale any thermal runaway is usually quickly noticed and brought under control with an ice bath and this remains a popular combination of reagents. LC 50 median concentration. Commonly abbreviated as DMF although this initialism is sometimes used for dimethylfuranor dimethyl fumaratethis colourless liquid is miscible with water and the majority of organic liquids.
Chemical synthesis using supercritical fluids. Dimethylformamide is odorless whereas technical grade or degraded samples often have a fishy smell due to impurity of dimethylamine.
Although currently impractical, DMF can be prepared from supercritical carbon dioxide using ruthenium -based catalysts. In the petrochemical industry DMF is used for the purification of acetylene from ethylene and butadiene from C4 streams.
Also the spinning of polyurethane based elastomers is performed from DMF based solutions.